In this post, Dr Aruchuna Mohanaruban tackles the most asked questions about the EndoBarrier – a medical device for the treatment of type 2 diabetes and obesity.
UK obesity rates have continued to rise at an alarming rate, with figures higher than any other developed nation. Strongly associated with obesity is the increased susceptibility to developing type 2 diabetes (T2DM) which currently affects 3.2 million of the UK population. Bariatric surgery – a type of surgery aimed at inducing weight loss – usually by altering the stomach and/or intestines has revolutionised the treatment of these conditions and can lead to a 60% remission in diabetes. However, with demand for this type of surgery outstripping supply, there is a greater need to develop non-surgical alternatives to combat the ever-rising obesity and diabetes epidemic. (more…)
As the festive season approaches, one wonders how our bodies prepare for the enormity of food that will be ingested in a relatively short space of time. In the UK alone, the average person consumes 7000 calories on Christmas Day alone. This is three times the recommended calorie intake per day, and most of us will have reached the recommended calorie intake before Christmas lunch has even been served. And of course, it’s not just about eating more. We are also a great deal more sedentary, with the average person in the UK spending 5.5 hours a day in front of the television over the Christmas period desperately awaiting reruns of Blackadder and yet another Christmas special!
Of course, this massive increase in consumption over the festive period inevitably means we put on weight, with research showing maximum weight gain reached within 10 days of Christmas Day, peaking around 3 January, and then falling. However, despite this relatively rapid increase in weight in the space of a few days, approximately half of the weight gained seems to remain until the summer months or beyond. The cumulative effects of this annual increase in weight during the holiday period likely contribute to one’s overall lifetime weight gain.
Obesity results from a mismatch between food intake and energy expenditure. So is this festive weight gain a result of eating too much and spending too much time on the sofa? What if it was more than just that? We now know that the gut is a crucial organ in the maintenance of energy homeostasis. It releases a whole host of hormones such as glucagon-like peptide-1 and peptide YY that regulate appetite in response to nutrient intake. Much of my work has focused on looking at the effect of dietary protein on appetite. High protein diets reduce food intake and improve body composition, and if people can stick to them, they lose weight. (more…)
Magazines and newspapers are full of so-called ‘tips’ or ‘advice’ for the image conscious, detailing extreme diets followed by the rich and famous to achieve dramatic weight loss, or new diets apparently supported by the latest scientific research. One example is the gluten-free diet, made fashionable particularly in the sporting world by former world number one tennis player Novak Djokovic (1). Having had a reputation for being physically weaker than his rivals, Djokovic was eventually diagnosed with coeliac disease and the resulting gluten intolerance. Eliminating gluten from his diet transformed his career.
Many have since adopted the gluten-free diet with the hope of boosting their own energy levels, but have had mixed results. Recent studies show that being ‘gluten-intolerant’ is hardly a medical condition that can be diagnosed and scientists have struggled to establish a mechanism for supposed gluten intolerance. So unless you suffer from coeliac disease triggered by gluten, following a gluten-free diet could do more harm than good, as gluten-free foods are often low in fibre and key nutrients, and high in sugar. (more…)