Author: Tony Goldstone

Could gut hormones help make Dry January last all year?

After the excesses of Christmas and New Year, it has become fashionable for January to be promoted as a time for reassessment and resolutions. There are promises and attempts at living a healthier lifestyle, including stopping drinking alcohol (‘Dry January’), joining that gym, stopping smoking, and eating better. However, we know how difficult it is to maintain behaviour change over the longer term. People start drinking excessively again, put back on the weight they lose, start smoking again, and their attendance at the gym wanes. For people who have hazardous levels of drinking, and those who are dependent on alcohol, this is particularly problematic.

If people manage to stop drinking alcohol, we know that there are high relapse rates. In some studies, 60% of people with alcohol dependence have started drinking alcohol again after 6 months of abstinence. This is often precipitated by exposure to social events and situations where there is drinking, and stresses with family, job, and social circumstances. What is needed are strategies to help prevent relapse into drinking. While psychological and group support can be of benefit, there is also a potential role for medications to help reduce the craving for alcohol and the response to stress.

The Division of Brain Sciences in the Department of Medicine at Imperial College London are currently running a research study in this area. We are investigating the potential benefit of a completely novel therapeutic strategy to prevent relapse in alcohol dependence. This is the ‘Gut Hormone in Addiction’ (GHADD) Study, funded by the Medical Research Council. This is targeting hormones from our guts, which can act on our brain to influence eating and addictive behaviours. (more…)