In this post, Dr Richard Kelwick explores exosomes – the tiny vesicles that may hold great therapeutic potential.
The adult human body is composed of around 30 trillion cells! That’s a lot of cells, and researchers are still figuring out the remarkable processes that govern how our cells are exquisitely organised into the complex tissues, organs and systems that make up our bodies. In order for our cells to co-ordinate and organise themselves correctly they need to be able to communicate with each other at the molecular level. Cells can communicate with each other using a variety of different ways, either by physically tugging on neighbouring cells, or by secreting proteins, hormones and many other types of signalling molecules. Cells can also send exosomes to each other. (more…)
One year on from receiving her A-level results, Eva Tadros reflects on her first year of medical school.
How did you feel when you opened your A-level results last year?
It was all such an incredible adrenaline rush, to be perfectly honest. I experienced a whole spectrum of emotions – anxious, excited, worried, thrilled and petrified – all at once! I had built up that moment in my head for so long and I had envisioned every possible scenario and every single way it could work out – how I’d feel if I actually got the grades and got into my dream university and how it’d feel if I didn’t and what steps I would take afterwards. It was a little exhausting waiting for results day for so long and then it’s a little underwhelming after you open them because you’re just like – okay so what’s next? (more…)
Originally published on Dr Nick Hopkinson’s blog and reproduced here with permission, this post looks at the Tobacco Industry’s dark history of appropriation and subversion of science.
“It ain’t no new thing” sang Gil Scott Heron in 1972, condemning the appropriation of black culture by white recording artists. A recent research paper published in Tobacco Control throws light on Tobacco Industry appropriation and subversion of science. Their goal, to prevent or delay measures which reduce their ability to market products that are among the leading causes of death worldwide (1). (more…)
Healthcare and Design MSc student Peter White makes the case for why we need to think outside the box when it comes to innovation in healthcare.
Have you ever looked at something and thought, “how on earth did no-one invent that before?” You know the feeling. It’s the one you get while staring numbly at a copy of Harry Potter – all the while wondering how the idea of a boy who goes to school went unwritten for so long. It’s the one people probably had when the first guy rolled by with casters on the bottom of his chair. Even Facebook seems like such a simple idea in hindsight.
Forget happiness or sadness or the feeling of ‘it’s coming home’. It’s this constant ‘so close yet so far’ that’s the prevailing emotion in my life right now. A perpetual reminder that, yes, I’ll never be Mark Zuckerburg, or even a Google elf for that matter. All this is compounded by the fact that, according to my shiny laminated ID card, I’m supposed to be a healthcare design masters student at St Mary’s hospital in London, a building so old it seems to look down enviously at the geriatric ward within. (more…)
For World Hepatitis Day, Dr Ana Ortega-Prieto explains why she switched her research focus from hepatitis C to hepatitis B – a virus that continues its global spread despite an available vaccine.
When I first started to work on hepatitis C virus (HCV) for my PhD, the general conviction was that it was a dangerous pathogen with very unsuccessful treatments. In the past years, this has completely changed; patients used to endure one year of treatment with severe side effects, but can now expect just three months of treatment, which is generally well tolerated. The truly impressive part here is that treatment success went up from below 50% to well over 90%. This has triggered the World Health Organisation (WHO) to aim for the eradication of all viral hepatitis by 2030 – a very ambitious goal. (more…)
Giskin Day makes the case for Imperial’s new Humanities, Philosophy and Law BSc – a pathway for medical students to combine the arts with medical science.
This year we celebrate the 70th anniversary of the NHS, but there is another birthday worthy of celebration. In 1948, the term ‘medical humanities’ was first used. George Sarton, who coined the phrase, believed that increasing specialisation in science and medicine failed to provide the framework for understanding the intellectual context and human significance of scientific developments. Medical schools around the world are increasingly coming to the same conclusion and incorporating humanities into medical education. (more…)
With the Wimbledon finals taking place on its famous grass courts this weekend, allergy expert Dr Mohamed Shamji explains how there may be hope for hay fever sufferers.
Strawberries and cream, queuing and of course, tennis are all the things you would associate with the Wimbledon Tennis Championships that climaxes this week in London. This tournament traditionally marks the end of the grass court season, which for the relief of many hay fever sufferers also signals the grass pollen season is drawing to a close. Headlines, guidance and warnings about hay fever are abundant at this time of year due to the large socio-economic impact it presents and here at Imperial College London, we are hoping to reduce this through our research into the disease and how we can treat it. (more…)
Originally published on the NIHR Blog and reproduced here with permission, Professor Andrea Rockall, Clinical Chair of Radiology at Imperial, provides an insight into whether AI can enhance human detection of bone disease.
Myeloma is a disease that affects the skeleton and can be difficult to pick up at an early stage because symptoms are often quite vague. People who suffer from myeloma may be generally more tired than usual due to anaemia and may have aching bones. As the disease progresses, thinning of the bones may result in fractures, particularly of the spine, and this may be the first time that the diagnosis is picked up. The kidneys may also be affected due to an increase in myeloma proteins circulating in the bloodstream getting caught up in the delicate kidney tubules that filter the blood. If the disease is picked up early, some of these problems can be prevented. (more…)
Three Imperial College London medical graduates reflect on how their final-year elective in medical outreach inspired local school children to aim higher and spark scientific curiosity.
Going on a medical elective is one of the highlights of medical school. During our final year of the MBBS programme at Imperial, we completed our elective in medical education with the Imperial College Primary Health Care Department.
Throughout our elective, one of the concepts we focused on was social accountability; how we could better our approach as medical students and as a university to improve medical outreach. (more…)
Dr John Tregoning explains how the use of animals in science is properly regulated and why it’s so important to respiratory research, which could impact millions of lives.
Respiratory infection is one of the main causes of disease and death throughout the world, claiming 3 million deaths worldwide in 2016. The symptoms range from the mild (a runny nose) to the extremely serious (pneumonia, hospitalisation and respiratory failure). These infections have a large economic burden both directly in medical costs and indirectly in working days lost. They also represent a potential risk for causing major pandemics; one hundred years ago the 1918 flu outbreak led to the death of 50-100 million people, significantly more than the whole First World War. There is a clear need to understand why we get sick after respiratory infections and critically we need new drugs to reduce the burden of disease. For example, there is an urgent need for a new influenza vaccine that could prevent future pandemics. (more…)