Blog posts

A breath of fresh ‘AIR’ in the study of lung repair and regeneration

NHLI researchers Róisín Mongey and Dr Sally Kim provide an insight into developing a new tool – the AIR model – for lung research and drug development.

Lung diseases represent a significant global health burden costing the NHS upwards of £1 billion annually. A hallmark of chronic and acute adult lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis (IPF) and COVID-19, is lung damage. The lungs are usually capable of repairing damage but in some cases, this does not happen or the repair process goes awry for example going into overdrive and causing more damage. The result of this lack of repair or abnormal repair is persistent tissue damage and declining lung function.

There are almost no treatments available to repair the lung damage in these diseases. A bold, new approach to identify novel lung repair treatments for these diseases is needed. Unfortunately, there are several roadblocks to the development of curative treatments, the primary one being that we don’t fully understand how repair happens in the healthy lung under normal circumstances. The bottom line is that unless we can figure this out, it is unlikely that we will be able to develop successful new repair treatments. (more…)

This Christmas is the time to be patient, not to become one

This festive period Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

As vaccines bring hope, Professor Helen Ward reflects on the emotions felt and lessons learned in a year confronting COVID-19.

What a strange year. For me, it has been full of contradictions. From one moment to the next I can feel sadness, frustration, anger but also pride and satisfaction. And guilt.

Sadness at the loss of life and the chronic ill-health that COVID-19 has brought, and for the loss of livelihoods and bleak futures for even more people. Frustration at the response of political leaders when vital decisions have been delayed, and anger that the pandemic has resulted in worsening social inequalities. Pride at my small part in the response, as an advocate for public health action when needed, a researcher co-leading one of the largest epidemiological studies (REACT), and an educator delivering a rapid online course to share the science of the COVID-19 response with over 100,000 learners. But also guilt that I have a secure and well-paid job that I can do safely from home, and that I have found research this year the most stimulating and satisfying of my career. Sometimes that enjoyment seems wrong.

My research career has focused on infectious disease epidemiology, particularly the control of HIV and sexually transmitted infections (STI), alongside teaching public and global health. I look back now and see how much of my career has been training for this pandemic challenge, and has taught me lessons that are very relevant for COVID-19.  From my HIV and STI research and clinical work, I learned about the complexities of controlling these infections. Understanding these “social” diseases requires a range of scientific approaches from basic immunology through mathematical modelling to anthropology. (more…)

Finding ‘me’ in the fight against inequality

This festive period Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

Dr Sarah Essilfie-Quaye, Project Manager in Research Strategy, discusses how we can all do more to address structural racism in academia.

I used to describe myself as an ‘early retired scientist’ – I left the lab not because I no longer loved research, but due to a series of challenges and roadblocks. However, on reflection, regardless of any career choices I made, it was unlikely I would become a professor. Because I am a woman; a woman who is Black; of African descent – Ghana, to be specific (#GhanaJollof!).

The harsh reality

To have a successful career in academia, I saw becoming a professor as the top of the achievements list, and while this is a tough goal for anyone, it is much, much tougher for some. I looked for Black women professors at Imperial. I think I was looking for my role models. Unfortunately for me ‘computer said no’, the answer was there were none. Zero. Nada. Zilch. This hugely influenced my decision to move away from academia and towards university administration, as I thought I was more likely to be able to achieve a stable and successful career that way. This was a decade ago, and despite now finally becoming part of a supportive team, I am still on short-term and part-time contracts. For this to happen I had to leave a permanent (albeit part-time) post elsewhere at Imperial – due to the toxic environment and lack of allies.

During my career, I have come to understand several key issues around race, and these include how under-represented Black women are at Imperial. There are still no women that look like me as professors. Nor in any permanent academic roles. In the whole of the UK there are only 35 professors who identify as Black women out of 21,000. And as I currently keep trying to highlight, while 25 per cent of Imperial staff are from a Black, Asian or ethnic minority (BAME) background, only 9 per cent are in senior positions, and how many of those are Black…? (more…)

Be the change you want to see in medicine

This festive period Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

Our first wise woman is Dr Sonia Kumar, Director of Undergraduate Primary Care Education and MEdIC (Medical Education Innovation and Research Centre).

My drive and motivation have always been underpinned by a strong and unshakable desire to make a difference, to try my best to make the world a better place. As you age you start to question where your underlying values come from, where and when did they start and from whom.

My father was a child of the Partition

Caught on the wrong side of the Indian border, my father as a very young child was forced to flee his then native country and travel with my grandmother, aunts and uncles, in the dead of the night on a train where children were muffled, and babies thrown overboard so the train could safely and silently make its way across the border. Years later he arrived in the UK in his twenties in search of new beginnings and despite the discrimination and racism of the 60s, he and my mother like many other immigrants of that time, showed untold strength and sacrifice to give us the next generation a better life.

Being a second-generation British Asian growing up in 70s and 80s Britain, I have not always had an easy ride. However, I am constantly reminded and humbled by the resilience and determination of my father and his forefathers and the opportunities and equality they fought for. It is an absolute privilege to honour those sacrifices and continue their legacy by ‘standing on the shoulders of giants’  in all aspects of my work. (more…)

Our Entrepreneurial Journey — a gait to better care?

Master’s student Emre Yavuz reflects on the highs and lows of taking part in a virtual hackathon – from designing an app to predict the risk of Dementia to pitching to 16 judges!

During lockdown I came across a post about a virtual hackathon called ‘Code to Care’, focusing on finding sustainable healthtech solutions which was run by Imperial College Business School. Having worked with Virtual Reality for my undergraduate dissertation, I knew there was something I could bring to this event! Through a Zoom speed-dating event during the hackathon, I connected with three other like-minded individuals who were all interested in using mobile technology to help lessen the burden of the lives of those stricken by Dementia.

We had decided to focus creating an app to help predict one’s risk of Dementia and monitor their disease progression, and had just three days to make our final pitch as convincing as possible in just two minutes. Based on the research suggesting a potential correlation between gait patterns and cognitive decline, we felt that focusing our app on the use of gait analysis would be a fruitful venture. (more…)

Clement Price Thomas and a once-in-a-lifetime operation

Westminster Medical School – one of the schools that formed Imperial College School of Medicine – has been home to many pioneers. But few can claim a connection to royalty.

Sir Clement Price Thomas, student and surgeon at Westminster and one of the fathers of thoracic surgery, rose to fame after an operation on King George VI. Read on to learn just how challenging this procedure would have been.

The reign of George VI was a turbulent time for the monarchy. At the end of a brutal world war and the dissolution of the largest empire the world has ever seen, the King’s health took a turn for the worse.

Because of the King’s chest problems, Sir John Weir, the Royal Family’s doctor, called in a lung disease expert, Geoffrey Marshall, and chest expert, Sir Robert Arthur Young. After X-rays and a bronchoscopy revealed a malignant tumour in his left lung, the King’s physicians set to work organising a secret operation. They all agreed that Clement Price Thomas was the best surgeon for the job.

Setting up the makeshift theatre

The operation was planned for 22 September 1951 at Buckingham Palace. But the Buhl room clearly wasn’t designed for major surgery, despite the equipment brought in for the occasion. With the stakes so high, Price Thomas demanded that the palace install emergency lighting in the room. The palace agreed – and even moved the changing of the guard to St James’s Palace to make sure the surgical team were not disturbed by the noise outside.

On Sunday 23 September 1951, the room was ready and Price Thomas, his two surgical registrars and his scrub team set to work. (more…)

Why plain packaging for cigarettes does not increase illicit trade

Dr Anthony Laverty discusses new findings that quash the argument that plain cigarette packaging increases illicit tobacco trade.

Australia was the first country in the world to introduce standardised, or plain, packaging for cigarettes and tobacco. The move was the product of a long-running campaign from the public health community and meant that the packets are allowed no branding; just the product name in standard font, colour and size. Since Australia brought in these measures, the UK followed in 2017, as did Ireland and France, increasing the number of countries in the world which restrict one of the key avenues for the tobacco industry to advertise their products. (more…)

A letter to our taught students and their loved ones

This is an open letter from Mr Martin Lupton, Vice-Dean of Education to taught students in the Faculty of Medicine and their loved-ones.

Dear Students and their friends and families,

My eldest son has recently returned to University in the UK and, even though I work in both the health and education sector, I have to acknowledge that I have a certain level of anxiety about him. It is very difficult to read the news about all that has happened during this time of COVID and not to worry.

I am telling you this because I want you to understand that I have some inkling of what you may be feeling right now, particularly if you come from overseas or your daughter, son or relation, has just started their university life. The first thing I want to say is “Welcome to the Faculty of Medicine”. We are very proud of what we have achieved during this global pandemic; the Faculty of Medicine at Imperial College has been a key player contributing to the world’s understanding of the virus, the mapping of the virus, teaching people about the virus and developing a new vaccine. However, that is not all that we have been doing. (more…)

COVID-19 vaccine diaries: part two, safety first

Justine is a participant in Imperial’s COVID-19 vaccine clinical trial – here she discusses how the trial is progressing. 

“Am I immune?” “Could I be immune?”

These are questions that have been unavoidably circling in my head ever since I received an experimental coronavirus vaccine as part of a clinical trial led by Imperial College London. 

Every time I exercise, take public transport, do my weekly food shop, socialise with those close to me, I’ve been trying to quash this invisible shield that part of my brain believes might be there, shrugging off any potential encounters with the SARS-CoV-2 virus. 

I didn’t enter this trial so that I’d get a free pass to behave irresponsibly in the midst of a pandemic, which is frighteningly rearing its ugly head again in my home country. I always knew that immunity was never a certainty, having never been tested in human beings before. I was more confident that it wasn’t a dangerous thing for me to do, and certain that it was a good thing to do. 

And by participating, I have certainly helped to prove both of these latter points. I’ve had two shots of the vaccine, which works by instructing my cells to make fragments of the coronavirus, thereby prompting my immune system to react and, hopefully, keep a protective memory of the threat. I’ve had no side effects at all; not even a sore arm. The devil on my shoulder sort of wished for even a little redness where the needle went in, that I could wear proudly as a mark of my contribution to research.  (more…)

A public health Insight into the UK’s new obesity strategy

Public health researcher Charan Gill provides an inside look at the Government’s new obesity strategy and discusses if it’s the way to tackle the obesity crisis.

In July the UK government released the ‘Tackling Obesity: empowering adults and children to live healthier lives strategy’. As a public health researcher, I was eagerly waiting for this to be published and I know many others were also anticipating what was going to be released in the document.  This new strategy has received a great deal of criticism, and although it does raise valid and important points, it has left many confused. Despite this, there have also been several important issues raised which needed to be addressed. Over recent years, several obesity strategies have been published, but I want to highlight some key positives from this strategy and how I see it working.

Firstly, I want to recognise how great it is to see the government emphasising on public health and prevention. Acknowledging that there are public health services that can offer huge benefits to the public and will in turn have beneficial impacts and reduced strain on the NHS. The strategy claims that the government will expand weight management services and the NHS Diabetes Prevention Programme which are a few services which can offer preventative support.  These suggestions are fantastic and offer practical resources to support individuals who want to make healthy lifestyle changes. (more…)