Category: Department of Surgery and Cancer

Going with our guts to find new treatments: faecal microbiota transplantation at Imperial

Dr Ben Mullish and Dr Julie McDonald explore the ins and outs of faecal microbiota transplants – it may sound unpleasant but this procedure is proving to be an effective way of treating chronic gut infections.


Most of us can name (or may have had first-hand experience of) a number of different bacteria that can cause serious gut infections, such as Salmonella or Campylobacter.  However, what is less well-known is that we also have billions of bacteria living in our guts that normally do us no harm at all.  Some actually have important contributions towards our health – including prevention of bacterial pathogens entering our gut and causing infections.  Collectively, this huge population of microorganisms living inside our digestive tracts is often referred to as the ‘gut microbiota’.  If anything happens to us that disturbs or kills off members of this gut microbiota – such as exposure to antibiotics, or surgery – then we have greater vulnerability to gut infections, and particularly from a form of bacteria called Clostridium difficile. (more…)

Why curing breast cancer isn’t a piece of cake

This Breast Cancer Awareness Month, Dr Luca Magnani unravels the complexity of cancer research, from recent advances in genomics to the power of patients in research. 


In today’s fast-paced world in which everything quickly rotates, spins loudly for your clicks and sights, deciding where to focus our attention is a decisive factor. When trends come and go at lightning pace, it is somewhat surprising that October is still Breast Cancer Awareness Month. I’m glad we can still manage to stop and reflect on what this means. Last year we discussed how Breast Cancer Awareness Month has evolved in the era of social media and marketing. This year I thought we could be more optimistic and discuss when October becomes ‘tea and crumpet’ appreciation month. (more…)

You don’t need to be a doctor to change healthcare

HELIX design studio

Healthcare and Design MSc student Peter White makes the case for why we need to think outside the box when it comes to innovation in healthcare.


Have you ever looked at something and thought, “how on earth did no-one invent that before?” You know the feeling. It’s the one you get while staring numbly at a copy of Harry Potter – all the while wondering how the idea of a boy who goes to school went unwritten for so long. It’s the one people probably had when the first guy rolled by with casters on the bottom of his chair. Even Facebook seems like such a simple idea in hindsight.

Forget happiness or sadness or the feeling of ‘it’s coming home’. It’s this constant ‘so close yet so far’ that’s the prevailing emotion in my life right now. A perpetual reminder that, yes, I’ll never be Mark Zuckerburg, or even a Google elf for that matter. All this is compounded by the fact that, according to my shiny laminated ID card, I’m supposed to be a healthcare design masters student at St Mary’s hospital in London, a building so old it seems to look down enviously at the geriatric ward within. (more…)

The Bionic Radiologist: can artificial intelligence enhance human detection of bone disease?

artificial intelligence bone disease

Originally published on the NIHR Blog and reproduced here with permission, Professor Andrea Rockall, Clinical Chair of Radiology at Imperial, provides an insight into whether AI can enhance human detection of bone disease.


Myeloma is a disease that affects the skeleton and can be difficult to pick up at an early stage because symptoms are often quite vague. People who suffer from myeloma may be generally more tired than usual due to anaemia and may have aching bones. As the disease progresses, thinning of the bones may result in fractures, particularly of the spine, and this may be the first time that the diagnosis is picked up. The kidneys may also be affected due to an increase in myeloma proteins circulating in the bloodstream getting caught up in the delicate kidney tubules that filter the blood. If the disease is picked up early, some of these problems can be prevented. (more…)

Could the EndoBarrier be the next weapon of mass reduction?

Endobarrier

In this post, Dr Aruchuna Mohanaruban tackles the most asked questions about the EndoBarrier – a medical device for the treatment of type 2 diabetes and obesity.


UK obesity rates have continued to rise at an alarming rate, with figures higher than any other developed nation. Strongly associated with obesity is the increased susceptibility to developing type 2 diabetes (T2DM) which currently affects 3.2 million of the UK population. Bariatric surgery – a type of surgery aimed at inducing weight loss – usually by altering the stomach and/or intestines has revolutionised the treatment of these conditions and can lead to a 60% remission in diabetes. However, with demand for this type of surgery outstripping supply, there is a greater need to develop non-surgical alternatives to combat the ever-rising obesity and diabetes epidemic. (more…)

“You don’t defibrillate asystole…” and other arguments with creatives

Dr Christopher Peters provides an insight into life behind the scenes as a TV medical advisor for leading programmes such as Eastenders and Holby City.


It is a favourite pastime of anyone who works in healthcare to scoff at the mistakes we see when medicine is portrayed on film. From the back-to-front chest X-ray on Scrubs to the miraculous success rates of chest compressions in soaps we love to mock. However, for the last four years I have been working with various TV programmes to try to inject a degree of realism without dampening the drama.

This started with Holby City when I helped out on set, making sure that operating scenes looked realistic and that the actors could pass off as surgeons. This was my introduction to the tension between realism and plot. Being a medical drama, Holby had the budget and resources to try and get things right, but even they couldn’t keep viewers interested if they showed a lovely routine list of day cases where nothing goes wrong! (more…)

How machine learning will transform the way we look at medical images

Machine learning

Dr Tim Hoogenboom, a Research Sonographer, looks at the promise and perils of machine learning in medical imaging.

Medical imaging is key in today’s delivery of modern healthcare, with an immense 41 million imaging tests taking place in England in every year. Thousands upon thousands of patients safely undergo imaging procedures such as X-ray, ultrasound, and MRI every day, and the product of these tests – the images – play an essential role in informing the decisions of medical professionals and patients in nearly every area of disease. (more…)

Would you give the gift of a kidney to a stranger in need?

Kidney donations stranger

It is the season of giving, so we look at how kidney donations from strangers are giving kidney disease patients a second chance at life. 


As far as generous Christmas presents go, donating your kidney seems for many at the extreme end. However, for a few lucky kidney disease patients, this is the gift of a lifetime. Known as unspecified or non-directed altruistic kidney donation, this form of live organ donation is on the rise, and could potentially wipe the waiting list if more stepped forward. I met Frank Dor, a consultant transplant surgeon and Head of Transplantation at Imperial College Healthcare NHS Trust, who has carried out hundreds of live organ donations. (more…)

How a little Mo effort can make a big difference

To mark Movember, PhD student Akifumi Shibakawa explains how Movember cash is funding prostate cancer research at Imperial and how to get involved in the fundraising. 


It’s that time of the year again, when men grow moustaches around the globe. It all started in 2003, when two guys in Australia had the idea to make moustache-growing fashionable again. For a greater cause, they made this campaign about men’s health and established the Movember Foundation. As you may know, the campaign became an international phenomenon, attracting over 300,000 participants in more than 20 countries in 2016. (more…)

The Pathology Museum’s top treasures

Pathology museum

Tucked away in Charing Cross Hospital is Imperial’s best-kept secret: The Pathology Museum. Housing a 2,500-strong collection of anatomical specimens, the Pathology Museum contains some rare and unique artefacts dating from 1888, including the first hysterectomy performed in England.


Carefully curated by the Human Anatomy Unit (HAU), the specimens are grouped together based on organ systems, creating a well-arranged display of human pathology. The museum’s primary function is to help educate medical and biomedical students to diagnose diseases. The museum also hosts a number of conference and short courses in pathology for experienced professionals.

The collection incorporates specimens from across the Faculty of Medicine’s founding medical schools, there are an astonishing 4,000 further specimens not on display. This vast archive provides a snapshot of the historical foundations of the medical school. (more…)