Category: Department of Brain Sciences

How research is helping to understand and break the self-harm cycle

Rachel Rodrigues sheds light on her research on understanding the brain mechanisms that motivate people to self-harm – can we untangle the circuits to break the cycle?


Many of us will know someone who has self-harmed or may even have personal experience of it. This isn’t surprising considering how common it is, particularly in adolescence and young adulthood. Unfortunately though, only about 20% of young people receive help from clinical services for their self-harm, and as much as 50% aren’t receiving any help, even from people close to them, meaning that they are having to cope with it on their own.

For some people self-harm could become more frequent and intense over time and coupled with it also being the strongest predictor of future suicide attempts, this lack of intervention for self-harm is concerning. The aim of my PhD research within Imperial’s Mood Instability Research Group is to find out why young people continue to self-harm. We hope to translate our findings to improve interventions for self-harm. (more…)

How does coparenting influence children’s behaviour?

Ellen Grimas draws on her PhD research investigating the role of coparenting in children’s development and behaviour.


I remember a child psychiatrist saying during a keynote at a conference that the only mental health that mattered was child mental health. This made me think back to working at a mental health crisis house, where I was often struck by how many people said their symptoms first emerged in childhood or adolescence. Research tells a similar story, with recent figures suggesting that 75% of mental health problems emerge before the age of 18, and yet only 30% of people reported receiving proper and timely support.

This is worrying as there is a wealth of research suggesting that early intervention is not only beneficial for the individual and their family, but also for society as a whole. Childhood is clearly a key period in the development of our mental health, and also offers a unique opportunity to intervene. So, although it may not be the only mental health that matters, it is evidently an incredibly important component. In the context of an over-stretched NHS, the idea of low-level interventions in childhood that could help avoid the need for services in later life is a powerful one. (more…)

Back down to earth: From astrophysicist to desk-bound medical scientist

In this post, Dr Sujata Sridharan shares her career path, from graduating with an astrophysics degree to being a postdoc in brain imaging.


I’m not a scientist, not really. At least, that’s what I’ve heard countless times from my non-academic friends, and sometimes even colleagues. I’ve deduced that this belief dates back to my decision to take an MPhys in Physics with Astrophysics as my undergraduate degree.

Physics first

As a (comparatively) fresh-faced 18-year-old, I undertook my first degree at the University of Manchester, (somewhat naively) under the impression that astrophysics involved a lot of actual stargazing. My first year was a pleasant 60:40 split of lectures and laboratory-based work. Albeit the latter was rather generalised; at one point I remember making a hologram of a bronze Buddha statue for no apparent scientific reason. My main concern at that point was that I hadn’t yet bumped into Brian Cox, who had recently taken up teaching duties at the university in between – what we physicists considered – glamorous filming of the ‘Wonders of the Universe’ documentary series. (more…)

Challenges in motor neurone disease: from ice buckets to new therapeutic targets

Challenges in Motor Neurone Disease: from ice buckets to new therapeutic targets

On MND Global Awareness Day, Professor Jackie de Belleroche looks at how increased awareness and collaboration, alongside advances in genetic and molecular research, offers hope for the future.


Without doubt, the last few years have seen phenomenal developments not only in research, but also in public awareness of just how devastating a condition motor neurone disease (MND) is. There is hardly anyone who has not heard of MND thanks to Professor Stephen Hawking, well-known to the public as an outstanding scientist who was diagnosed with the condition at the age of 21. The ALS “ice bucket challenge” certainly caught the imagination of the international community too, as well as raising £88m in a single month for MND research across the world (it’s important to note here that MND is usually referred to as amyotrophic lateral sclerosis [ALS] outside the UK). (more…)

From friend to foe: what drives MS to turn our immune systems against us?

For MS Awareness Week, researchers from our Division of Brain Sciences explain how their efforts in understanding the mechanism behind MS is driving the search for new drug targets. 


I have always been fascinated by how the immune system protects our body by identifying attackers and fighting them off. It’s a remarkable undertaking: it must recognise and protect us from any number of harmful molecules produced by a huge array of invading organisms. Sometimes, however, this system can go wrong. For instance, in the case of multiple sclerosis (MS), the immune system erroneously attacks the myelin – a fatty covering that protects our nerves – in our own central nervous system. This produces the chronic accumulation of demyelinated MS lesions that lead to the clinical symptoms of the disease. (more…)

Banking on brains: the quest for new methods of treatment for Parkinson’s

Parkinson's

For World Parkinson’s Day, Ben Tilley highlights how brain tissue donated to Imperial’s Tissue Bank is instrumental in finding new methods of treatment for Parkinson’s. 


My personal journey with Parkinson’s disease (PD) research started six years ago. It was the summer of 2012, and while enjoying the London Olympics and preparing myself to start Medical School at Imperial College London, my father was developing symptoms of PD. When the diagnosis was made I knew what my career goal would be; I had to study this disease and I had no ambitions other than to become a neurologist in the future. (more…)

Could gut hormones help make Dry January last all year?

Dr Tony Goldstone

In this post, Dr Tony Goldstone looks at the role of gut hormones in controlling alcohol addiction and how they may provide a basis for future treatment. 


After the excesses of Christmas and New Year, it has become fashionable for January to be promoted as a time for reassessment and resolutions. There are promises and attempts at living a healthier lifestyle, including stopping drinking alcohol (‘Dry January’), joining that gym, stopping smoking, and eating better. However, we know how difficult it is to maintain behaviour change over the longer term. People start drinking excessively again, put back on the weight they lose, start smoking again, and their attendance at the gym wanes. For people who have hazardous levels of drinking, and those who are dependent on alcohol, this is particularly problematic. (more…)

Alcohol Awareness Week: seeking a responsible alternative

For Alcohol Awareness Week, Professor David Nutt explains how his latest research venture, an alcohol-free beverage, could address the dangers associated with alcohol consumption. 


Most of us are aware that chronic, heavy alcohol consumption and binge drinking leads to a plethora of health issues including liver damage and addiction. However, many of us are still unaware of the dangers associated with even moderate alcohol consumption or the cumulative effects that alcohol can have on our health. So just what are those regular trips to the pub, or the frequent cocktails after work really costing us? (more…)

How teaching life skills can help children with ADHD

Dr Susan Young, a clinical psychologist and author, is turning conventional ADHD treatment on its head with a series of programmes for children and adults.


I started working with young people with attention deficit hyperactivity disorder 25 years ago. Over the years, our knowledge and understanding of ADHD has come a long way – mostly down to scientific research – taking the condition from a relatively unheard one to a household one. Too often, we associate ADHD with children, however it’s now recognised to be a lifetime condition with many undiagnosed adults continuing to experience symptoms throughout their lives, despite the abundance of international guidelines on the assessment, treatment and management of ADHD. With many young people reaching adulthood with undiagnosed ADHD, or even misdiagnosed, they will not receive the optimal treatment for their symptoms and associated problems. Unfortunately, many will not reach their potential, and for some, they feel their future is bleak. (more…)