With London’s biggest running event of the year upon us, sport-expert Tim Grove gives a low down on the benefits of running for a healthy heart.
Is physical activity good for us?
London Marathon – the biggest sporting spectacle of the year – is fast approaching. This Sunday will see over 40,000 runners take part in the gruelling 26.2-mile course starting at Blackheath and finishing in front of Buckingham Palace. The event is highly televised with elite runners, celebrities, politicians and fundraisers all taking part together. The London Marathon has gained popularity since its inception in 1981 and has raised over £450 million for charity, making it the world’s largest annual fundraising event. With its high media profile, the London Marathon certainly sparks the enthusiasm of the general public with many taking to streets in the bid to train for next year’s event or for shorter distance races. (more…)
In this post, Dr Anusha Seneviratne breaks down the conundrum of cell death and how this process protects our bodies from blood clots.
Your cells die every day. Don’t worry, your body is protecting itself. In a process known as apoptosis or programmed cell death, cells that are no longer needed commit suicide. Some cells are only required for a short time, they may be infected by a virus or develop harmful cancerous mutations. Cell death is also an essential part of development from an embryo. For example, mouse paws begin as spade-like structures and only form the individual digits as the cells in between die. During apoptosis the cells fragment into smaller apoptotic bodies, and their cell surface is flipped open to display lipid molecules called phosphatidylserines, which act as an ‘eat me’ signal to recruit cells called macrophages to engulf them, before their contents spill out and damage the surrounding tissue. This is a process known as efferocytosis. (more…)
In the post, Neil Dufton asks: How can we bring together imaging technology, art and philosophy to shape scientific research?
When we think of vascular health we are often guilty of presuming that we are primarily discussing the heart. Clearly the heart has a major role to play in regulating your blood flow; once our blood has exited the heart it must supply nutrients to every organ of our body and back to the heart in a cycle that takes about one minute. Any hindrance from a cholesterol-blocked artery or blood clot can have catastrophic results – however by the time we reach retirement our circulation will have exceeded 30 million laps around the body! This incredible feat is made possible by our blood vessels that not only form a vast network during your development in the womb, but are also constantly growing and remodelling throughout our life time. Our Vascular Science research group at the National Heart and Lung Institute is particularly interested in endothelial cells – the cells that line every blood vessel in our body. We want to understand how they work together to grow and form new vessels (a process called angiogenesis), as well as how they maintain these structures in response to injury and disease. (more…)
From gluten-free to detox diets, Dr Anusha Seneviratne dissects the scientific evidence (or lack of) behind eccentric diets.
Magazines and newspapers are full of so-called ‘tips’ or ‘advice’ for the image conscious, detailing extreme diets followed by the rich and famous to achieve dramatic weight loss, or new diets apparently supported by the latest scientific research. One example is the gluten-free diet, made fashionable particularly in the sporting world by former world number one tennis player Novak Djokovic (1). Having had a reputation for being physically weaker than his rivals, Djokovic was eventually diagnosed with coeliac disease and the resulting gluten intolerance. Eliminating gluten from his diet transformed his career. (more…)