Archive for the ‘Achievements’ Category

Dr Claire FletcherDr Claire Fletcher, of the Androgen Signalling Laboratory, Division of Cancer, has been awarded a prestigious Young Investigator Award by the Prostate Cancer Foundation of the USA. The stated aim of the PCF in creating these awards, which are very rarely awarded outside of the US, is “to identify a cohort of future research leaders who will keep the field of prostate cancer research vibrant with new ideas.”

Claire will be using the award to pursue her innovative translational research programme at Imperial College, mentored both by Professor Charlotte Bevan in her host laboratory and also by Prof Johann de Bono at the Institute of Cancer Research, cementing and developing the collaboration between the 2 laboratories and indeed institutes. Her work focuses on identification of microRNA drivers of therapy resistance in prostate cancer, with the aim of both increasing therapy options and also of providing biomarkers to enable effective patient stratification.

I am thrilled to have received a Prostate Cancer Foundation Young Investigator Award. This grant will allow me to vastly accelerate our promising research into the mechanisms through which prostate cancers continually evolve to develop resistance to even the most effective drugs – an area which remains poorly understood.

In the future, this knowledge will help us to develop more effective therapeutics and tailor treatments to individual patients.” – Dr Claire Fletcher.

 

Abstract

Systematic Identification of MicroRNA Drivers of Resistance to Novel Therapeutics in Advanced Prostate Cancer – Exploitation as Stratification Biomarkers and Drug Targets

Prostate cancer (PC) is the most prevalent malignancy of Western males, affecting 1 in 8 men in their lifetime. Relapse on first-line anti-androgen treatment occurs almost invariably, leading to advanced ‘castration-resistant PC (CRPC), metastasis and patient death. Next-generation therapeutics that target the androgen receptor (AR) or alternative oncogenic signalling pathways, alongside taxane-based chemotherapeutics, demonstrate efficacy in the CRPC setting. However, only 50% of men respond to taxane-based chemotherapy, and acquired resistance to novel AR-targetting agents is emerging due to intra-tumoral androgen production or AR amplification. This necessitates urgent identification of new therapeutics and drug targets for CRPC, and discovery of resistance-predicting biomarkers.

MiRs are small 18-22nt RNAs that negatively regulate gene expression. They can function as ‘oncomiRs’ or tumour suppressors and show altered expression in CRPC. They are readily detectable in bodily fluids from patients, demonstrating considerable biomarker potential, and represent ideal therapeutics due to their small size, high stability and low toxicity. I have previously demonstrated that miRs dramatically alter AR activity, growth and metastatic potential in CRPC and that levels of putative oncomiRs are altered by novel CRPC drug treatment. Further, miRs are associated with chemotherapy resistance.

This project will use small RNA sequencing and functional assays to identify miRs that play fundamental roles in development of resistance to mechanistically-distinct novel CRPC agents in clinically-relevant CRPC models, and will generate miR biomarker ‘signature’ arrays that can predict resistance to such therapeutics. This will inform clinical management of PC and avoid the considerable morbidity and toxicity of agents that may not benefit a given patient. Development of therapies targeting resistance-promoting miRs may provide an additional treatment option for CRPC patients, increasing disease survival.

Charlotte Bevan
Professor of Cancer Biology
Androgen Signalling Laboratory

 

 

 
Mr Chris Lattimer

Mr Chris Lattimer

It gives me great pleasure to inform you that Imperial College have once again won a prestigious international award from the Josef Pflug Vascular Laboratory (Ealing Hospital & Imperial College).

This time is was the Bronze Award for best oral presentation at the American College of Phlebology held in Orlando this year at their 29th Annual Congress.

The title was: ‘Evaluation of the pumping performance of common peroneal nerve stimulation using air-plethysmography‘.

The award ceremony was held at the Hilton Bonnet Creek Hotel on 15th November 2015 where Dr Armen Roupenian presented the certificate to me with a monetary prize.

The work explained how the calf muscle pump works in augmenting the venous return and the contribution of the GEKO device in achieving this target. Suggestions were made as to how the device could be improved to maximise efficiency in the prevention of DVT.

Mr Chris Lattimer
Honorary Clinical Senior Lecturer
Department of Surgery and Cancer

 

 

 

Professor Beate Kampmann has been nominated by the Medical Research Council (MRC) to join AcademiaNet – Expert Database for Outstanding Female Academics.

Professor Beate Kampmann The Robert Bosch Stiftung, in cooperation with Spektrum der Wissenschaft (Nature Publishing Group), has set up this exclusive expert database in 2010. It was launched by German Chancellor Dr. Angela Merkel and it is the only Web site of its kind that shows profiles only of outstandingly qualified women who are best in their field. They all have been nominated by highly recognized science and research institutions. To date, more than 1,700 profiles of female top-class researchers of all disciplines are in the database.

The website (www.academia-net.org) is supplemented by editorials such as up-to-date news reports, scientific articles and interviews with female scientists and has registered over one million clicks to date. The high number of visitors to the database is not the only indication of its success: all four female scientists awarded the Leibniz Prize in 2014 – the most important research prize in Germany – are members of AcademiaNet.

 

 

 

The South African Medical Research Council (SAMRC) paid tribute to some of the country’s leading medical researchers at its prestigious SAMRC Scientific Merit Awards in Cape Town.  The esteemed President’s Award as well as the Platinum, Gold and Silver Awards were presented to scientists whose work has had a monumental impact on health science in South Africa.

Professor Wilkinson, Senior Wellcome Trust Research Fellow in the Department of Medicine, received the Gold Award on 29 October. His work has focused on clinical and immunological aspects of tuberculosis – particularly in the context of HIV infection.

Find out more on the Scientific Merit Awards website.

 

 

 
 

Faculty of Medicine awards update

July 25, 2015
by Medicine Notifications

Mr Chris Lattimer wins second prize at the 16th Annual European Venous Forum Meeting

Prize_LattimerMr Lattimer collected the award on behalf of his team at the EVF Annual Meeting in St. Petersburg, Russia, for their presentation; ‘Increasing thigh compression pressure correlates with a reduction in the venous drainage index of air plethysmography.’

This highly competitive award has provided a grant of £1,500 for Mr Lattimer to present his team’s work on venous drainage at the 2016 Annual Meeting of the American Venous Forum, to be held in Orlando, Florida, next February. This is acknowledged to be the most prestigious venous meeting globally.

Dr Mick Jones receives multiple teaching awards in 2014/15

Dr Mick JonesDr Jones, Reader in Molecular Medicine in the Department of Medicine and Course Director of the MSc in Molecular Medicine, picked up numerous teaching awards this year:

  • The top prize at the Department of Medicine Teaching Awards, 2015 for Outstanding Contribution to Education
  • The awards for Outstanding Contribution to Teaching and Supervision and the Top Contributor to Teaching based on the 2014 Teaching Hours Survey
  • The award for the Best Teaching for Postgraduates at the 2015 Student Academic Choice Awards

Professor Charlotte Bevan appointed to the Executive Committee of the BACR

Professor of Cancer Biology, Charlotte Bevan will take up the new role at the British Association for Cancer Research in the autumn of this year.

Professor Simon Taylor-Robinson elected to Royal College of Physicians Council

In July Simon Taylor-Robinson, Professor of Translation Medicine in the Department of Medicine, was elected to the Council of the Royal College of Physicians.

Dr Brijesh Patel elected to European Society of Intensive Care Medicine NEXT committee

Dr Patel, a Clinical Lecturer in the Department of Surgery and Cancer, has been elected to the European Society of Intensive Care Medicine NEXT (Network of EXecptional Trainees) committee.

In June he was also awarded a 2015 American Thoracic Society abstract scholarship.

 

 

 

 

Norah Schuster PrizeThe School of Medicine are very pleased to announce that two of our 5th year Medical students, Zeena Mougammadou-Aribou and Sam Tindall both won prizes at this year’s Royal Society of Medicine Norah Schuster Prize.

This prestigious prize is awarded for the best student essay relating to the history of medicine. Zeena and Sam (seen below at the Award Ceremony in April) won the prize for the mini-projects which they conducted during the History of Medicine specialist course, taken as part of their intercalated BSc. They each received a £100 book token and a year’s membership of the Royal Society of Medicine.

Zeena’s mini-project considered a surgical procedure which was marketed in the 18th century for the management of teething in children. Interestingly, until the 19th century a large portion of child mortality was attributed to teething, which was perceived to be a dangerous period in child development. The surgical procedure was invented by a man named Joseph Hurlock and it involved cutting the gums of teething children so the teeth could come through unobstructed. Hurlock used clever and innovative marketing techniques to ensure that his procedure became widely used. However, these techniques were also controversial; for example, criticising the reliability of nurses and the effectiveness of other techniques used for teething infants.

From left: Dr Michael Weatherburn (Sam's project supervisor), Zeena M-A, Dr Emily Mayhew, Sam and Dr Neil Tarrant (Zeena’s Supervisor and History of Medicine course head) a t the Norah Schuster Awards Ceremony

From left: Dr Michael Weatherburn (Sam’s project supervisor), Zeena M-A, Dr Emily Mayhew, Sam and Dr Neil Tarrant (Zeena’s Supervisor and History of Medicine course head) a t the Norah Schuster Awards Ceremony

Sam’s mini-project examined how a strong focus on the Western Front during World War 1 meant that the Italian Front was overlooked in historical writing and therefore in public perception. The war took place in the Alps between Italy and the Austro-Hungarian Empire. The terrain and weather conditions made this battle unique in many ways when compared with the rest of WWI. The injuries and ailments afflicting soldiers fighting in this region are therefore very different to those perceived to have affected soldiers at the time. This includes frost bite and the risk of avalanche in the winter, and lightning strikes and malaria in the summer.

The School of Medicine would like to congratulate Zeena and Sam on their excellent achievement and to thank Dr Neil Tarrant, the History of Medicine Course Director, and his team for all of their work on the course.

Nicole Barnes
Curriculum Administrator (BSc Pathways)
Faculty Education Office (Medicine)

 

 

 

athena silver

The Department of Medicine was delighted to hear last week that it has been granted an Athena SWAN Silver award in recognition of its commitment to address the underrepresentation of female academics in university STEMM departments.

The achievement reflects the fruits of actions completed and the impact of changes made since the department’s Bronze award in 2013. The gap between numbers of male and female academics is slowly closing, and academic promotion application and success rates are now slightly higher for women than men.

From the start of its Athena SWAN journey in 2012 the department (headed by Professor Martin Wilkins) took a broad approach by setting out to make changes to culture and organisation that would benefit all staff and students, and “building a strong and supportive academic community” is integral to its mission.

Developments since the Bronze award include a thriving mentoring scheme that is now being adopted by other departments, an annual Welcome reception for all new staff (and informative Welcome packs), an Academic & Family Life panel discussion programme open to the wider College, a DoM Life website, promotion support team and an Early Career Committee.

Many challenges remain for a department of nearly 1000 people spread across six campuses: ensuring that progress so far is both embedded and sustainable, fostering a supportive and interactive culture, and forging a clear departmental identity.

Progress is driven by a diverse Development & Opportunities Committee led by Dr Jane Saffell and supported by HR Liaison Officer Mrs Meriel Cartwright. Within this, an Early Career Committee co-Chaired by Drs Amy Birch and Ed Roberts spearheads initiatives for postdocs and PhD students.

If you are interested in the work of the committees, or would like to see the Athena SWAN submission and action plan, please visit the DoM Life website.

 

Dr Jane Saffell
Senior Lecturer
Department of Medicine

 

 

 

OLYMPUS DIGITAL CAMERAMadeleine Openshaw, a 5th year student at the Imperial College School of Medicine won the Student Presenter prize at the Society for Academic Primary Care (SAPC), London and South East Regional conference in January 2015.

Her emotive presentation entitled ‘In Loving Memory’: the role of sentimental objects in childhood bereavement’ was based on research performed during her humanities intercalated BSc at Imperial.

Maddy will be presenting her work again in June at the Annual GP Teachers Conference for our community based Imperial Primary Care teachers.

 

Dr Joanne Harris MRCP MRCGP MA(Med Ed)
Deputy Head of Undergraduate School of Medicine
Imperial College London

 

 

 

Dr Mahiben Maruthappu, Senior Fellow to the CEO of NHS England, and junior doctor in North West Thames Foundation School, becomes the first person from the NHS to make Forbes 30 under 30 since the list’s inception.

Dr Mahiben MaruthappuDr Maruthappu serves as Senior Fellow to Simon Stevens, Chief Executive of NHS England, where he recently contributed to the Five Year Forward View, and in January, with Sir Bruce Keogh, launched the NHS Innovation Accelerator (NIA), a programme aiming to identify twenty tried and tested innovations from across the world and scale them in the NHS to improve patient care.

Outside of clinical practice he has a background in health systems research, policy and entrepreneurship, having published over 60 peer-reviewed articles, receiving over 50 awards and honours, advising organisations ranging from startups to the WHO, and serving as a Kennedy Scholar at Harvard University.

Dr Maruthappu said “It was exciting to be included in the Forbes 30 under 30 list. Working in North West Thames has exposed me to a broad range of opportunities, both inside and outside of clinical practice, that I’m sure led to my nomination”.

Philipa Shallard
Foundation School/Undergraduate Services Manager
Faculty of Medicine

 

 

 
 

Best paper award won at the #design4learning conference

December 1, 2014
by Maria Toro-Troconis

Dr Maria Toro-Troconis, Mr Ashish Hemani and Dr Kevin Murphy won best paper award at the #design4learning conference run by the Open University (OU) and the Higher Education Academy (HEA) on the 26 & 27 November 2014 . HIG01S0002_Logo_Primary_Blue_RGB_MV1ou-logo

Following a competitive selection the paper entitled ‘Learning Design in the 21st century. Blended Learning Design Tool (BLEnDT©) and MOOCit©’ won the best paper award.

 

The paper discussed The Blended Learning Design Tool (BLEnDT©) developed by Dr Toro-Troconis at the School of Medicine and the implementation and findings in the design of a blended learning course for the Respiratory Muscles tutorial in Year 1 of the MBBS course.

 

The Blended Learning Design Tool (BLEnDT©) introduces an instructional framework for the design of blended learning approaches identifying the learning outcomes that lend themselves to interactive self-guided online learning following an Instructionist approach and the learning outcomes that are best suited for face to face delivery or online delivery following a Constructivist/Collaborative approach.

 

BLEnDT© is currently used at the School of Medicine at Imperial College London and by the Imperial College Curriculum Development team – Lee Kong Chian School of Medicine.

 

The School of Health Sciences at City University London, the Centre for Technology Enhanced Learning at King’s College London and the University College London (UCL) are also collaborating in the use of BLEnDT©.

 

More information about BLEnDT©: http://www1.imperial.ac.uk/medicine/elearning/blendt/
#design4learning conference: http://design4learning.org.uk

#BLEnDTImperial
twitter-logo
 
 

Dr Maria Toro-Troconis
E-Learning Strategy and Development Manager
Faculty of Medicine

 

 

 
 

CIPM celebrates staff awards

November 14, 2014
by Ellen Clegg

Centre for Infection Prevention and Management (CIPM ) collaborators Dr. Eimear Brannigan and Enrique Castro-Sanchez have had cause to celebrate recently.

Earlier this year Dr. Brannigan was nominated for the Imperial College Teaching Excellence Award for 2013-14. The award was set up in 2003 to recognise excellent teaching among NHS staff. We are delighted to announce that the nomination was successful and Dr. Brannigan will be presented with her award at a ceremony on Tuesday 25th November at 5.30pm in the Glenister lecture theatre at Charing Cross.

Our senior research nurse Enrique Castro-Sanchez has been awarded a travel scholarship by the Florence Nightingale Foundation Trust. The scholarship is to enable Enrique to undertake a study in South Africa, Mozambique and Rwanda on building nursing capacity in antimicrobial stewardship: learning from low and middle income countries. The study builds on CIPM’s existing partnership with hospitals in Rwanda, including the work to reduce neonatal mortality and maternal and paediatric infection through improved patient safety in Rwanda, funded by THET Partnerships for Global Health.

Ellen Clegg
Education Project Manager
Centre for Infection Prevention and Management
Faculty of Medicine

 

 

 

The MEd Surgical Education Community would like to congratulate 2013 alumnus Mr Andrew Wainwright for winning the Robert Jones Gold Medal from the British Orthopaedic Association, after submitting an essay based on his MEd studies.  Andrew, a consultant surgeon and Training Programme Director in Oxford, completed his MEd in Surgical Education with a Distinction and a dissertation entitled “A good pair of hands”. In the prize-winning essay he discussed the themes of competence, apprenticeship and craftsmanship in orthopaedic surgery today. By exploring the essence of what ‘having a good pair of hands’ means to surgeons, he proposed how this could improve the way that orthopaedic surgeons learn, teach, and assess surgical skills.

Susan Clark
Honorary Senior Lecturer, Adjunct Professor
Department of Surgery & Cancer
Faculty of Medicine

 

 

 

poppylamberton-profilepicPoppy Lamberton was recently shortlisted for The Women of the Future Awards – the largest national search for exceptionally talented women, which unearths the next generation of high-flying women across nine industries, including technology, media, business, arts and science. Poppy, a Junior Research Fellow in the Department of Infectious Disease Epidemiology, was shortlisted for the 2014 Science category. Poppy works on neglected tropical diseases, which are often endemic in the world’s poorest rural and urban communities. Her research currently focuses on parasitic infections such as Bilharzia and River Blindness, with the aim to maximize the success of treating populations in Africa. Poppy’s research utilizes field epidemiological data, laboratory experiments and population genetics to understand parasite population structure, transmission dynamics and the effects of long term mass drug administration programmes. Poppy is also passionate about public engagement with science, talking at a range of schools and working closely with STEM and the Natural History Museum on events such as Science Uncovered and Nature Live.

Dr Poppy Lamberton
Junior Research Fellow
School of Public Health
Faculty of Medicine

 

 

 

drWe are pleased to announce that Mr Pankaj Sharma has been appointed Professor of Neurology at the University of London and Head of a new cardiovascular research institute at the Royal Holloway College. He will continue a clinical appointment at Imperial College NHS Trust.

Pankaj Sharma is Consultant Neurologist at Imperial College Healthcare NHS Trust (formerly Hammersmith Hospitals). He has doctorates from Cambridge and London Universities and was a Fulbright Scholar at Harvard Medical School USA.

He leads the internationally renown Imperial College Cerebrovascular Research Unit (ICCRU) and has published widely in major international journals.

Professor Sharma’s clinical interests include: headache, stroke, dizziness, seizures, fits and epilepsy.

Please visit this page for details of Mr Sharma’s experience and publications.

 

Pankaj Sharma MD PhD FRCP
Head, Imperial College Cerebrovascular Research Unit (ICCRU)
Imperial College London & Hammersmith Hospitals

 

 

 
 

IUA Award from the XXVI World Congress in Sydney

October 2, 2014
by cdharris

The Josef Pflug Vascular Laboratory of Imperial College has recently won the prize for the best oral presentation at the XXVI World Congress of the International Union of Angiology 10th – 14th August 2014 in Sydney, Australia with entry number #820. The certificate was given to Mr Christopher Lattimer MBBS, FRCS, MS, PhD from Professor John Fletcher, Chairman of congress and President elect of the IUA, on behalf of the team and collaborators.

The award was for recognising that D-dimer levels taken from the leg in patients with chronic venous insufficiency were increased in comparison to their arm blood samples. The research arose from the hypothesis that local blood samples would be a better reflexion of local pathology than a systemic sample from the arm which has been altered through several organs and capillary beds. This led to the development of the ankle cubital D-dimer ratio (ACDR) which may be a more specific test at detecting pro-thrombotic states in the leg, like venous disease or a deep vein thrombosis (DVT). The advantage of the ACDR over a single arm sample is that it is not dependent on the age of the patient and it is unrelated to the type of measuring assay. Future studies are underway to determine whether this test may improve the specificity of D-dimer as a screening test in the detection of DVT.

The prize was awarded to our team which includes our overseas collaborators, Professor Jawed Fareed, Professor Debra Hoppensteadt and Daneyal Syed from the Department of Thrombosis and Haemostasis, Loyola University, Chicago, USA. The rest of our team from the Josef Pflug vascular laboratory (http://josefpflugvascular.com) at Ealing hospital and Imperial College includes Dr Evi Kalodiki, Senior Research Fellow, and the head of our Department, Mr George Geroulakos.

 

 

 

The School of Medicine has seen an excellent improvement in the 2014 National Student Survey result, with overall satisfaction increasing 7% to 90% – putting it 4% above the sector average.

Martin Lupton, Head of the Undergraduate School of Medicine, puts the improvements down to greater emphasis within the school on listening to students’ feedback:

“We’ve spent a lot of time actively listening to our students and it’s clearly had an impact. We have strong staff-student liaison groups, town hall meetings with our students and I have a lunch each week with a group of 12 -14 students randomly chosen from across the school.  These help us identify exactly where there are issues and how we can best address them. It was this kind of feedback that led us to revamp our tutoring system, bringing in a smaller number of well-trained tutors with allocated time to undertake the role.”

Susan English, Director of Education Management, also highlighted the strong sense of community within the medical school as a contributing factor to the positive environment:

“Led by Jenny Higham, Vice-Dean (Education and Institutional Affairs), there’s been a push to raise the profile of the School and develop a stronger identity which I think has helped increase the feeling of community for our staff and students. When you have over 2,000 students operating over four teaching sites, 30 hospital sites and dozens of general practices it can be a challenge to instil a sense of belonging.  We have also increased the emphasis on celebrating students’ progression through their studies.  For example, we have a welcome dinner with all first year students and staff and a ‘white coat’ ceremony, when they commence their Year 3 clinical attachments so that staff and students come together to celebrate this milestone.”

This year’s results for medicine have seen improvements across all of the surveyed areas. As well as overall satisfaction increasing, improvements in Academic Support of 13% and Organisation and Management of 15% were the highest by any department College-wide.

Chris Harris, Quality and Educational Development Manager added:

“It’s important to stress though that we’re not complacent. We’re over the moon with this year’s results but there is lots more still be done. We’ve made a commitment to continue listening to our students and working with them to improve their experience and that’s what we’re going to do.”

Chris Harris
Quality and Educational Development Manager
Faculty of Medicine

 

 

 

The Department of Medicine is delighted that Professor Ten Feizi is the recipient of the prestigious 2014 Rosalind Kornfeld Award from The Society for Glycobiology. The Rosalind Kornfeld Award for Lifetime Achievement in Glycobiology was established in 2008 to honour the distinguished scientific career and service to the Society by Dr Rosalind Kornfeld. The award is given by the Society to scientists who have, over their professional lifetimes, made significant contributions with important impact on the field.  In Professor Feizi’s case this award is in recognition of her many achievements in the fields of structure analysis, immunology and function of glycans over nearly 50 years.

Imperial successfully recruited Professor Ten Feizi in 1994 when the Northwick Park Campus became affiliated with the College. Her research group was already a leading world centre in glycobiology, notably having established the specificity of human monoclonal antibodies for specific oligosaccharide sequences and the observed programmed changes in expression of blood group-related sequences during embryogenesis, cell differentiation and oncogenesis, research published in Nature that became a seminal publication in the field. The group then went on to introduce neoglycolipid (NGL) technology for lipid-linked oligosaccharide probes and in 2002 this became the first glycoarray system intended to encompass entire glycomes. This is currently the most diverse glycoarray system in the world, revolutionizing the molecular dissection of pathogen-host interactions as well as endogenous recognition systems. Recent highlights are assignments of the host cell receptors for the oncogenic simian virus 40 (SV40) and the pandemic A(H1N1) 2009 influenza virus. In recognition of the importance of this ground-breaking work, Prof Ten Feizi received recognition with membership to the Fellowship of the Academy of Medical Sciences.

Joanna Thompson
Divisional Manager, Division of Immunology & Inflammation
Department of Medicine

 

 

 

MIke SkinnerAt the beginning of June, Dr Mike Skinner (Section of Virology at St Mary’s) took over from Professor Janet Bainbridge as Chair of the Health & Safety Executive (HSE)’s Scientific Advisory Committee on Genetic Modification (Contained Use) – SACGM (CU). Dr Skinner has sat on SACGM (CU) since 2004, when it was formed to replace the former Advisory Committee on Genetic Modification (ACGM). The committee provides technical and scientific advice to HSE and other relevant authorities on all aspects of the human and environmental risks of the contained use of genetically modified organisms (GMOs). Its work therefore complements, and generally precedes, the work of  the Department for Environment, Food and Rural Affairs (DEFRA)’s Advisory Committee on Releases to the Environment (ACRE) which covers deliberate release policy. The remit of the committee is:

• To advise on the technical issues of individual activities notified under the Genetically Modified Organisms (Contained Use) Regulations 2000

• To provide advice on risk assessments for contained use activities involving GMOs

• To develop and update guidance on all aspects of contained use of GMOs including the Compendium of Guidance; a document that is well regarded both nationally and internationally

SACGM (CU) therefore helps HSE protect workers in industry, research and the health service (as well as the general public and wider environment) from any potential hazards attributable to genetically modified organisms (GMOs), while at the same time aiming to allow the research, production or application to progress in a safe manner. It concentrates on higher risk (Class 3 & 4) activities but also advises on the changing landscape of research, technological developments and disease threats, though in the latter case it overlaps with HSE’s Advisory Committee on Dangerous Pathogens (ACDP).

Like the other members of the committee, Mike says that the work has proved challenging but interesting and satisfying. Early in its life, it had to deal with issues concerning the industrial scale production of pre-pandemic vaccine against avian influenza virus H5N1, work which proved invaluable at the time of the unexpected emergence of the H1N1 pandemic in 2009. Indeed much of the committee’s deliberation has concerned assessment and control of recombinant influenza viruses created not just as vaccines but to help researchers understand the pathogenesis and host range of viruses emerging from animal reservoirs; the latter work has become somewhat more controversial following the publication of well-publicised ‘gain-of-function’ studies.

Within the clinical setting there are a burgeoning number of gene therapy constructs and recombinant vaccines that are entering clinical trials within hospitals and which are moving toward licensed clinical use. Data to support eventual approval for release of these vaccines through ACRE (and for licensure through the Medicines and Healthcare Products Regulatory Agency; MHRA) are conducted under contained use.

Mike is also looking forward to working with the those involved in the development of Synthetic Biology (a broad and rapidly developing area in research and industry, which falls under the remit of the GM regulations) and with those advising the authorities in other EU states (as EU legislation now shapes many of the relevant UK regulations).

 

 

 

A special commendation should go to Harriet Davidson and Frances Dixon, two final year students whose abstract was selected amongst a competitive field of primary care academics, to present at this year’s SAPC meeting held at Madingley Hall in Cambridge. They expertly and confidently presented the findings of an audit they conducted as part of their General Practice Student Assistantship coursework, and their responses to tricky questions from the audience was particularly impressive!

Frances and Harriet 20 02 2014   3

The audit analysed the use of chaperones for intimate examinations in primary care, an important topic for which GMC guidance was published in April 2013. As part of the audit they not only conducted a retrospective analysis of GP consultations, but also carried out a prospective survey of 91 patients to find out their views on being offered chaperones. They found that over two thirds of patients felt that chaperones should be offered but that less than a third would actually ask for one, concluding that patients want chaperones more than doctors think they do, and that we should be trying to overcome possible obstacles and offering chaperones as much as possible.

Following on from their success at Madingley, they also recently recorded a video of their presentation which will be shown at the Annual Teachers Conference for Primary Care Teachers held in June at Imperial College.

They deserve a special mention for this work given that they are currently in the midst of their finals, and we wish them both every future success!

Dr Joanne Harris MRCP MRCGP MA (Med Ed)
General Practitioner
Director of Curriculum and Assessment
Deputy Director of Primary Care Education

 

 

 

Lesley reganThe Department of Surgery & Cancer congratulates Professor Lesley Regan, on her election as Vice President for Strategic Development of the Royal College of Obstetricians and Gynaecologists.

The RCOG encourages the study and advancement of the science and practice of obstetrics and gynaecology, through postgraduate medical education, training development and the publication of clinical guidelines and reports on aspects of this specialty and service provision.

Professor Regan is Director of the Recurrent Miscarriage Service at St Mary’s, comprising of a multidisciplinary team that she has developed to provide comprehensive investigations and treatment for couples with a history of recurrent early and late miscarriages. Professor Regan is also President of the UK Association of Early Pregnancy Units, advisor to the NICE interventions committee, professional member of the Human Fertilisation and Embryology Authority and Research Licence Committee.

Shirely Line
Divisional Manager-Human Resources/Communications
Department of Surgery and Cancer

 

 

 
 

Professor John Warner Awarded OBE at Windsor Palace

December 9, 2013
by Al McCartney

Prof J O Warner OBEProfessor John Warner, a consultant paediatrician at Imperial College Healthcare NHS Trust, was awarded his OBE at Windsor Castle on 22 November. Speaking at his Investiture, Professor Warner said he was honoured to receive the award.

“It was unexpected and unasked for. I feel very flattered and honoured that my research and the research of my team has been recognised in this way.”

Professor Warner has been involved in food allergy research over the past 25 years. His research has focused on the early life origins of asthma and related allergic and respiratory disorders. He is currently working on a programme to improve knowledge and co-ordinate the management of children with allergies in general practices, nurseries, schools and home.

 

 

 
 

Imperial Winner in Round 2 of the NIHR New Media Competition

November 29, 2013
by Carol Fitzgerald

A short film documenting the experiences of patients that have taken part in research in North West London has been recognised as joint runner-up in the NIHR New Media Competition. Produced as a collaborative output between neighbouring arms of the NIHR infrastructure in Northwest London (i.e. the NIHR Imperial Biomedical Research Centre (BRC), NIHR Biomedical Research Unit (BRU) in Cardiovascular Disease, NIHR BRU in Respiratory Disease and NIHR CLAHRC Northwest London), the objective of this film was to promote patient participation by presenting an unbiased report from the patient perspective.

 

Dr Carol FitzGerald
NIHR Imperial BRC Research Officer

 

 

 
 

From the Dean of the Faculty

October 14, 2013
by Dermot Kelleher

Dear Colleagues,

Imperial College has figured at No 4 globally in the Times Higher Education (THE) World University rankings in the Category of Clinical, Pre-Clinical and Health, a rise of one place since 2012. This is excellent news and reflects strongly on the quality of our faculty and on the sustained excellence of the research and teaching at Imperial College. So thanks to all of you for helping to deliver this remarkable achievement which clearly reflects an extraordinary body of work. Every small contribution helps – from taking extra time over a worried student to discovery of a new pathway relevant to human disease or in translating research into policy.  The ability to translate does appear to be an important theme in this category with important implications in enhancing reputation.  We have a wonderful research eco-system in the Faculty of Medicine that enables us to convert our discoveries into real benefits for patients through our partnerships in the AHSC and the AHSN.

This theme of translation is also followed through in the Life Sciences table with Harvard ranked at No 1. The Citation in THE interestingly cites Harvard’s ability to accelerate the pathway from discovery to product through the Harvard Biomedical Accelerator Fund and the capacity to rapidly move from test-tube to clinic as a key factor in its success. As we look to the future with development of Imperial West looming on the horizon, there may be important pointers for us here in terms of our translational strategy. How we develop strategically with our international partners may be key to moving further ahead in the University rankings in the future.

Professor Dermot Kelleher MD FRCPI FRCP F MedSci AGAF
Dean of the Faculty of Medicine

 

 

 
 

PhD student awarded Ruth Bowden Scholarship

July 31, 2013
by Alex Blakemore

Dr Naomi Walker, a PhD student from the Department of Medicine, has been awarded the Ruth Bowden Scholarship (£5000) for her work on “Defining mechanisms of tissue destruction in TB and TB immune reconstitution inflammatory syndrome (TB-IRIS)”. The scholarship is part of the  British Federation of Women Graduates Scholarship Awards 2013,  which provides prizes for academic excellence to female PhD students in their final year.

Naomi’s success follows last year’s, where two Imperial students; Stephanie Walton and Lucy Thorne, also won awards.

Dr Alexandra Blakemore
Faculty of Medicine Ambassador for Women

 

 

 
 

Department of Medicine Young Scientist Day 2013

May 14, 2013
by Hayley Kendall

The Department of Medicine held its third annual Young Scientist Day (details of the 2012 young scientist day), chaired by Professor Wendy Barclay, on 24 April 2013. The event attracted large numbers of research students, postdocs and academic staff who had the unique opportunity to hear and see the range of research being undertaken across the Department.

Over 70 posters were displayed by research students in their 2nd and 3rd years from across the Department. Two Departmental panels of judges, comprising academic staff (Dr Kevin Murphy, Professor Julian Dyson and Dr Ramesh Wigneshweraraj) and Student Reps (Nathali Grageda, Lauren Capron, William Jackson and Ming-Shih Hwang), judged the posters.

The event was formally opened at 1400 by Professor Shiranee Sriskandan. Professor Sriskandan informed everyone of recent grant successes of the Department’s PhD students and Post Docs as follows:

3 successful Junior Research Fellow (JRF) applications, 2013:

  • Christopher Rhodes
  • Kathleen McCaffrey
  • Claire Turner

2 MRC Centenary Awards, 2013:

  • Nicki Lynskey
  • Anna Simmonds

Miscellaneous Awards:

  • Paul Turner (Post Doc), Paediatrics, successful in acquiring an MRC clinician/scientist award
  • Kelsey Jones (PhD student), Paediatrics, currently in the 3rd year of his PhD research based in Kenya, obtained a Gates foundation grant. This is to institute a trial of an innovative nutritional reconstitution formula for severely malnourished children.
  • Ben Bleasdale, PhD student, Virology, won 1st prize for his scientific essay in the Royal College of Science Unions Science Challenge, 2013. He was presented with his prize at the House of Lords by Lord Winston.
  • Moira Cheung, PhD student, Molecular Endocrinology, won the 2013 International Conference on Children’s Bone Health New Investigator Award
  • Apostolos Gogakos, PhD student, Molecular Endocrinology, won the  2013 British Endocrine Societies British Thyroid Association Prize
  • John Logan, Post Doc, Molecular Endocrinology, awarded  a £10,000 Society for Endocrinology Early Career Award in 2012/2013

Professor Barclay expertly Chaired the afternoon, introducing the postdocs’ high quality scientific presentations. The floor was handed to five postdocs who had been selected to orally present their research:

  • Nicki Lynskey, Division of Infectious Diseases:
    A Molecular Basis for Group A Streptococcal Hyper-encapsulation
  • David Bernardo Ordiz, Division of Infectious Diseases:
    Immune compartmentalization in the gastrointestinal tract: differences between ascending and descending human colon
  • Ana Cehovin, Division of Infectious Diseases:
    Specific DNA   recognition mediated by type IV pilins
  • Anna Herasimtschuk, Division of Immunology:
    Therapeutic immunisation in conjunction with IL-2, GM-CSF and rhGH improves CD4 T-cell counts and reduces immune activation in cART-treated HIV-1+patients: a phase I clinical study
  • Amy Birch, Division of Brain Sciences:
    The ablation of reactive astrocytes in APP23 mice induces spatial memory decline & increases amyloid plaque load

Following the above oral presentations, Ms Katie Anders, from the Postdoc Development Centre, drew everyone’s attention to the  Postdoc Development Centre and the ongoing support and development opportunities it offers to postdocs. Dr Claire Turner, recently awarded a JRF, then joined Professor Barclay at the poster and oral presentation prize announcement as follows:

Prizes were given to all Post Docs who had been selected to give an oral presentation.

Post Docs with Dr Claire Turner

  • 1st prizes for posters were given to Ian Harrison, Katherine McCullough, Mark Reglinska and Korina Li
  • 2nd prizes for posters were given to Yuliya Nigmatullina and Catherine Ong

Prizes for posters

At the end of the afternoon, refreshments were served in the breakout space providing an opportunity for networking and poster viewing. Thanks go to everyone who supported this event. Special thanks to the Postdoc Development Centre for financially supporting the event. Plans are now underway to build on its strengths to ensure its continuing success on an annual basis.

Hayley Kendall
Education Research Manager
Department of Medicine